Proteoglycomics: recent progress and future challenges.

نویسندگان

  • Mellisa Ly
  • Tatiana N Laremore
  • Robert J Linhardt
چکیده

Proteoglycomics is a systematic study of structure, expression, and function of proteoglycans, a posttranslationally modified subset of a proteome. Although relying on the established technologies of proteomics and glycomics, proteoglycomics research requires unique approaches for elucidating structure-function relationships of both proteoglycan components, glycosaminoglycan chain, and core protein. This review discusses our current understanding of structure and function of proteoglycans, major players in the development, normal physiology, and disease. A brief outline of the proteoglycomic sample preparation and analysis is provided along with examples of several recent proteoglycomic studies. Unique challenges in the characterization of glycosaminoglycan component of proteoglycans are discussed, with emphasis on the many analytical tools used and the types of information they provide.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Carbon membranes for gas separation processes: Recent progress and future perspective

Carbon membrane can be produced using a wide variety of polymer precursor materials via heat treatment process. A general concept route of precursor selection-preparation-modification-performance analysis platform for the carbon membrane has been proposed to promote the development of carbon membrane material for a wide range of application. The current review considers the recent progress of c...

متن کامل

Down Syndrome: Current Status, Challenges and Future Perspectives

Down syndrome (DS) is a birth defect with huge medical and social costs, caused by trisomy of whole or part of chromosome 21. It is the most prevalent genetic disease worldwide and the common genetic cause of intellectual disabilities appearing in about 1 in 400-1500 newborns. Although the syndrome had been described thousands of years before, it was named after John Langdon Down who described ...

متن کامل

State Support: A Prerequisite for Global Health Network Effectiveness; Comment on “Four Challenges that Global Health Networks Face”

Shiffman recently summarized lessons for network effectiveness from an impressive collection of case-studies. However, in common with most global health governance analysis in recent years, Shiffman underplays the important role of states in these global networks. As the body which decides and signs international agreements, often provides the resourcing, and is responsible for implementing ini...

متن کامل

Reverse Electrodialysis for Salinity Gradient Power Generation: Challenges and Future Perspectives

Salinity gradient energy, which is also known as Blue energy, is a renewable energy form that can be extracted from the mixing of two solutions with different salinities. About 80% of the current global electricity demand could potentially be covered by this energy source. Among several energy extraction technologie...

متن کامل

From innovative polymers to advanced nanomedicine: key challenges, recent progress and future perspectives: the second Symposium on Innovative Polymers for Controlled Delivery Suzhou, China, 11–14 September 2012 .

Recent developments in polymer-based controlled delivery systems have made a significant clinical impact. The second Symposium on Innovative Polymers for Controlled Delivery (SIPCD) was held in Suzhou, China to address the key challenges and provide up-to-date progress and future perspectives in the innovation of polymer-based therapeutics. At SIPCD, a stimulating panel discussion was introduce...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Omics : a journal of integrative biology

دوره 14 4  شماره 

صفحات  -

تاریخ انتشار 2010